Pleural Effusions

Despite the fact that sarcoidosis is a disease spread by international experts could not determine the exact cause of her appearance. The disease is associated with the presence of abnormal immune response, but it triggers remain unknown. One of the main reasons for which cases can be studied is the lack of animal models for this disease and the inability of the antigen that causes immune activation. Although extensive studies have been conducted, it can not determine which is the agent responsible for the occurrence of granulomas that characterize disease.a
Sarcoidosis remission-

The potential of the case is taken into account in all bacterial infections, medications, toxic exposure, genetic factors and autoimmune diseases. Most experts believe that sarcoidosis is the result of complex interactions between environmental factors and increased sensitivity to the host organism. After this interaction can activate the immune system, triggering inflammatory events in various organs, leading to granulomas.

Since the sarcoidotice lesions (granulomas) in the nodes found genetic material (DNA and RNA), from Mycobacterium tuberculosis, scientists have extensively studied the effect of bacteria on the appearance of the disease. Others suspect the bacteria Propionibacterium acnes, Streptococcus species, Borrelia burgdorferi, Mycoplasma species, and Nocardia species. According to the analysis of the (still) viruses such as Epstein Barr virus, herpes viruses, Coxsackie B virus, cytomegalovirus and retroviruses, and environmental factors (chemicals such as beryllium, aluminum, zirconium, titanium).

They are very important genetic factors, especially when considering simtpomele, disease severity and prognosis.Sarcoidosis is a chronic inflammatory disease that is characterized by an exaggerated immune response to unknown antigens, but is expected to target the disease found in organima.Znak disease, sarcoid granuloma most likely formed in response to persistent antigenic stimulus (producing a permanent incentive to maintain the abnormal immune response), but can not be eliminated (or at least neutralized) effectively.

Inflammatory cascade is initiated at the local level, which is driving more and more cells that release enzymes, cytokines, interleukins, which are nothing more than an attack, and maintenance of additional tissue injury. Tissues, particularly lung cancer, the mechanisms that fit with their own aggression, and secrete growth factors, tumor necrosis factor and cytokines.

As a result of this fight standing, acute inflammation turns from chronic local tissue will change the permeability, capillary (vascular) will change the mechanisms of cell proliferation, changes that will eventually lead to the appearance of granuloma. Persistent antigenic stimulation appears to be a key factor that maintains this inflammation is responsible for the disease.

Although sarcoidosis can occur in any organ and often affects the lungs, the granulomas can be described in the lymph nodes, eyes, ears, skin, liver, joints, nervous system and heart. Within the granuloma cells secrete growth factors that favor the occurrence of local fibrosis. This can sometimes be so severe that insufficient cause visceral.Symptoms of sarcoidosis can vary greatly from one patient to another, depending on the organs affected by disease. Most patients complain of dry cough, fatigue and shortness of breath, but the clinical picture may include the following:
- Chest pain, bone pain, abdominal pain;
- Fever, Malaysia, weight loss;
- Erythematous nodules, painful, present in the skin;
- Red eyes, reduced visual acuity and hiperlacrimatie;
- Painful joints, swollen;
- Pneumothorax, pulmonary atelectazii;
- Restrictive respiratory syndrome following pleural effusion (pneumonia),